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In the fifth installment of our #DiscoveringOligonucleotides series, we dive into the preclinical development phase. From research in vitro, which lays the groundwork, until validation in vivo, which brings promising therapies to clinical reality, therapeutic oligonucleotides, like all other drugs, need to be studied in depth before being tested in patients. In vitro research: the […]
Author Archives: oligofastx
15
Jan
Jan
Since the pioneering approval of Fomivirsen in 1998, the field of oligonucleotides has undergone a remarkable evolution, marking significant milestones in the treatment of various diseases. Despite initial challenges, oligonucleotide antisense oligonucleotides (ASOs) have re-emerged strongly, supported by technological innovations, growth in the rare genetic disease market and collaboration between diverse entities. Four therapeutic oligonucleotides […]
05
Jan
Jan
In this fourth installment of our #DiscoveringOligonucleotides series, we explore a crucial challenge for innovative drug development, including those based on therapeutic oligonucleotides: delivery systems. Challenges in the release of therapeutic oligonucleotides Therapeutic oligonucleotides have enormous potential to address a variety of diseases, from genetic disorders to neurodegenerative diseases. However, their efficacy is often linked […]
05
Jan
Jan
In this fourth installment of our #DiscoveringOligonucleotides series, we explore a crucial challenge for innovative drug development, including those based on therapeutic oligonucleotides: delivery systems. Challenges in the release of therapeutic oligonucleotides Therapeutic oligonucleotides have enormous potential to address a variety of diseases, from genetic disorders to neurodegenerative diseases. However, their efficacy is often linked […]
29
Dec
Dec
We are coming to the end of this year and through this post we want to reflect on the impact of OLIGOFASTX in the field of RNA in Spain. Beyond the individual responsibilities of each partner, we have worked in coordination with the aim of creating an industrial fabric at national level and to make […]
26
Dec
Dec
Therapeutic oligonucleotides represent a breakthrough technology in genetic medicine, specifically addressing diseases at the molecular level. In this third instalment of our #DiscoveringOligonucleotides series, we dive into the development process, from target finding to custom oligonucleotide design. Search and selection of new targets: innovative strategies In the search for more effective treatments, systems biology stands […]
28
Nov
Nov
In the field of medicine, orphan drugs have stood out as silent heroes, bringing hope to those facing rare and neglected diseases. The term “orphan drugs” was first coined in the 1980s in the United States. The designation is given to drugs intended for the treatment of rare diseases, defined as those affecting 1 in […]
21
Nov
Nov
In this second issue of #DiscoveringOligonucleotides, from the OLIGOFASTX consortium we want to introduce you to RNA therapeutics. In the field of medicine, RNA therapies stand as pioneers, offering new approaches and promising advances in the treatment of diseases hitherto thought unattainable. RNA therapies operate at the most fundamental level of genetic information, using different […]
16
Nov
Nov
Science Week is a unique opportunity to get closer to the fascinating world of science. During this week there are various activities and events where you can learn first-hand about the latest advances and discoveries in different areas of science. Don’t miss the opportunity to take part in Science Week and broaden your knowledge! Science […]
Technology
Challenges and ethics in the integration of Artificial Intelligence in the pharmaceutical industry
14
Nov
Nov
At the intersection of technological innovation and healthcare, artificial intelligence (AI) is emerging as a transformative tool in the pharmaceutical industry. This pairing promises to accelerate the discovery of new medicines, optimise production processes and improve patient care. However, with the promise comes a number of challenges and ethical conflicts that must be carefully addressed […]