OLIGOFASTX

OLIGOFASTX is a multidisciplinary project focused on the development of innovative therapies based on RNA oligonucleotides. Led by Sylentis (PharmaMar Group) and supported by other Spanish companies, it seeks to design, optimise and scale up the production of these treatments to address rare or undiagnosed diseases. Through the use of advanced technologies such as artificial intelligence and nanotechnology, OLIGOFASTX creates controlled and personalised release systems to maximise the efficacy and safety of therapies, promoting the growth of the biotechnology sector in Spain.

Guide to therapeutic oligonucleotides

This guide is an OLIGOFASTX initiative in which you can explore how therapeutic oligonucleotides are transforming therapeutic oligonucleotides are transforming genetic medicine.

Acess the download to the guide

Guide to therapeutic oligonucleotides

This guide is an OLIGOFASTX initiative in which you can explore how therapeutic oligonucleotides are transforming therapeutic oligonucleotides are transforming genetic medicine.

Access the download to the guide
articles of interest Videos of interest Visit the website

OLIGOFASTX

OLIGOFASTX is formed by Spanish companies focused on accelerating the discovery and development of oligonucleotide-based therapeutics for rare diseases with no medical solution.

OLIGOFASTXPartners

OLIGOFASTX, led by Sylentis (PharmaMar Group), had the participation of five other Spanish companies.

Design, modeling and AI
Nanotechnology and drug delivery
Therapies development
Production and scaling

Rare diseases addressed

The rare diseases addressed by the OLIGOFASTX Project are the following:

ARTICLES OF INTEREST

In our blog we explore the potential of oligonucleotides in genetic medicine to treat diseases at the molecular level.

The psychological and emotional implications of living with a rare disease

The psychological and emotional implications of living with a rare disease Living with a rare [...]

24
Oct
World Rare Disease Day: embracing the rarity of a leap year

In a leap year like the current one, where 29 February takes on a special [...]

29
Feb
Hope for patients with Fuchs’ Endothelial Corneal Dystrophy: Innovations in treatment

Today we talk in our blog about another of the rare diseases that the OLIGOFASTX [...]

31
May
Alström syndrome: a rare disease with many comorbidities and complications

Rare diseases (affecting fewer than 1 in 2,000 people) are an emerging global public health [...]

13
Apr
Cancer cachexia

Cancer cachexia is a complex metabolic syndrome characterized by marked loss of body weight, anorexia, [...]

16
Jan
Providing solutions for rare diseases: a priority for the UN

Perhaps the definition is not the most accurate, but in reality a rare disease does [...]

10
Jan
Retinitis pigmentosa, a genetic vision pathology

Every last Sunday of September is celebrated the International Retinitis Pigmentosa Day, one of the [...]

26
Sep
Steinert’s myotonic dystrophy: when muscles become unresponsive

Today is International Myotonic Dystrophy Day, a rare disease with no treatment or cure to [...]

15
Sep
Nobel Prizes 2024

At this year’ s 2024 Nobel Prizes , the awards in Medicine, Physics and Chemistry [...]

11
Oct
The Annual Celebration of Scientific Excellence: The Nobel Prizes

Each year, the world of science and research unites in a celebration of excellence, innovation [...]

09
Oct
The Most Excellent Nobel Laureates 2022: these were the winners in the categories of Chemistry and Medicine

The work of the most renowned scientists, artists and diplomats is rewarded every year at [...]

06
Oct
Approval, registration and marketing of therapeutic oligos

In this eighth and final instalment of our #DiscoveringOligonucleotides series, we delve into the process [...]

01
Apr
Clinical trials: a journey towards hope in rare diseases

Clinical trials have been a fundamental pillar in the advancement of medicine and pharmaceutical research. [...]

11
Mar
#DiscoveringOligonucleotides: exploring the synthesis and scale-up of therapeutic oligonucleotides

In this sixth installment of our #DiscoveringOligonucleotides series, we delve into the synthesis and scale-up [...]

02
Feb
Preclinical development of therapeutic oligonucleotides

In the fifth installment of our #DiscoveringOligonucleotides series, we dive into the preclinical development phase. [...]

19
Jan
Therapeutic oligonucleotide delivery systems

In this fourth installment of our #DiscoveringOligonucleotides series, we explore a crucial challenge for innovative [...]

05
Jan
Design of therapeutic oligonucleotides

Therapeutic oligonucleotides represent a breakthrough technology in genetic medicine, specifically addressing diseases at the molecular [...]

26
Dec
RNA therapies and their transformative impact on precision medicine

In this second issue of #DiscoveringOligonucleotides, from the OLIGOFASTX consortium we want to introduce you [...]

21
Nov
Introduction to Therapeutic Oligonucleotides: Transforming Medicine from Genetics

Therapeutic oligonucleotides have emerged as an exciting and promising class of drugs capable of offering [...]

08
Nov
The legacy of Jacob and Monod: the molecular biology revolution

François Jacob and Jacques Monod transformed our understanding of genetics and laid the foundations of [...]

30
Aug
Spiegelman’s Monster: a milestone in molecular biology

Sol Spiegelman was a leading American molecular biologist whose work revolutionised our understanding of nucleic [...]

05
Jul
Getting to know real-time quantitative PCR (qPCR)

Molecular biology has revolutionised our understanding of life and opened up a world of possibilities [...]

03
May
Fire and Mello’s discovery of siRNAs: master keys to fighting disease

Small interfering RNA molecules (commonly known by the acronym siRNA small interfering RNA) represent one [...]

30
Oct
Larry Gold and Craig Tuerk: Pioneers in the Discovery of Aptamers

Advances in science and technology are often the result of the dedication, passion and collaboration [...]

20
Oct
David Bartel and microRNAs

David Bartel (Birmingham, 1958) is a leading researcher in molecular and cell biology who has [...]

20
Sep
The experiment that helped crack the code of life

In 1961, Marshall Nirenberg and Heinrich Matthaei discovered the genetic code of living beings, which [...]

28
Apr
Tribute to Severo Ochoa, the Spanish biochemist who received the Nobel Prize for discovering the enzymes involved in RNA synthesis.

Of Spanish origin, the small and idyllic town of Luarca (Asturias) was the birthplace of [...]

22
Mar
Key articles for the understanding of therapeutic oligonucleotides

11
Dec
Frequently asked questions on therapeutic oligonucleotides

In the field of biomedicine, therapeutic oligonucleotides represent a real revolution. These synthetic DNA or [...]

18
Nov
The psychological and emotional implications of living with a rare disease

The psychological and emotional implications of living with a rare disease Living with a rare [...]

24
Oct
Clinical trials: a detailed look

In medical research, there are several types of clinical trials that are designed according to [...]

21
Jun
Getting to know real-time quantitative PCR (qPCR)

Molecular biology has revolutionised our understanding of life and opened up a world of possibilities [...]

03
May
What is the path to becoming an oligonucleotide researcher?

At OLIGOFASTX, we are dedicated to the development and research of therapeutic oligonucleotides for rare [...]

25
Apr
World Rare Disease Day: embracing the rarity of a leap year

In a leap year like the current one, where 29 February takes on a special [...]

29
Feb
Orphan drugs not to forget anyone

In the field of medicine, orphan drugs have stood out as silent heroes, bringing hope [...]

28
Nov

VIDEOS OF INTEREST

In the channel you will find interviews with oligonucleotide experts, videos with the innovation in the OLIGOFASTX project and shorts of scientific and educational interest.

PROJECT WEBSITE

On the project website you can find all the information. From our mission and vision, to the partners, diseases and technologies researched in more depth. In addition, you will have access to a wealth of informative and interesting content in our full blog.

Visit the website