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The discovery of ribozymes in the 1980s revealed that RNA can not only store information, but also catalyse chemical reactions like enzymes do. This finding not only changed our understanding of cell biology, but also opened the door to new RNA-based therapies. What are ribozymes? Ribozymes, or ribozymes (a chimera word derived from ‘ribonucleic acid’ […]
Category Archives: Technology
06
Sep
Sep
siRNAs represent one of the most revolutionary discoveries in modern biotechnology. They date back to the experiments of Andrew Fire and Craig Mello in 1998, who first described the phenomenon of RNA interference in the nematode C. elegans nematode and were awarded the Nobel Prize in Medicine in 2006. In their research, they observed how […]
22
Aug
Aug
Oligonucleotides are used in numerous scientific applications, from biomedical research to drug development. In all of them, for oligonucleotides to be effective, it is essential that they are free of impurities. The purification of oligonucleotides is therefore a critical step in their manufacture. It is what is known as the downstream process within the production […]
16
May
May
Numerous types of oligonucleotides are synthesised every year for a wide variety of applications in laboratories and hospitals around the world. However, to fully understand this process, it is crucial to explore the origins of oligonucleotide synthesis and its connection to the evolution of modern biotechnology. The field of biotechnology has been shaped by a […]
15
Mar
Mar
Biotechnology has expanded our understanding and ability to address human health challenges. However, the path to clinical development of biotechnology innovations remains an intriguing challenge, with only a few innovations that have succeeded in becoming transformative tools and therapies. In this article, we explore the latest trends in healthcare biotechnology, focusing on RNA-based vaccines and […]
International Biotechnology Day 2024, Technology
Oligonucleotide biosynthesis: driving precision medicine towards a sustainable future
26
Jan
Jan
Precision medicine has seen extraordinary advances in recent years, driven largely by research into oligonucleotide biosynthesis. These tiny fragments of nucleic acid have emerged as key players in the development of highly targeted therapies that could revolutionise the treatment of diseases ranging from genetic to complex. Oligonucleotide biosynthesis is a process in which bacteria are […]
15
Jan
Jan
Since the pioneering approval of Fomivirsen in 1998, the field of oligonucleotides has undergone a remarkable evolution, marking significant milestones in the treatment of various diseases. Despite initial challenges, oligonucleotide antisense oligonucleotides (ASOs) have re-emerged strongly, supported by technological innovations, growth in the rare genetic disease market and collaboration between diverse entities. Four therapeutic oligonucleotides […]
05
Jan
Jan
In this fourth installment of our #DiscoveringOligonucleotides series, we explore a crucial challenge for innovative drug development, including those based on therapeutic oligonucleotides: delivery systems. Challenges in the release of therapeutic oligonucleotides Therapeutic oligonucleotides have enormous potential to address a variety of diseases, from genetic disorders to neurodegenerative diseases. However, their efficacy is often linked […]
28
Nov
Nov
In the field of medicine, orphan drugs have stood out as silent heroes, bringing hope to those facing rare and neglected diseases. The term “orphan drugs” was first coined in the 1980s in the United States. The designation is given to drugs intended for the treatment of rare diseases, defined as those affecting 1 in […]
Technology
Challenges and ethics in the integration of Artificial Intelligence in the pharmaceutical industry
14
Nov
Nov
At the intersection of technological innovation and healthcare, artificial intelligence (AI) is emerging as a transformative tool in the pharmaceutical industry. This pairing promises to accelerate the discovery of new medicines, optimise production processes and improve patient care. However, with the promise comes a number of challenges and ethical conflicts that must be carefully addressed […]
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