Category Archives: Discovering Oligonucleotides

In this eighth and final instalment of our #DiscoveringOligonucleotides series, we delve into the process of approval, registration and commercialisation of therapeutic oligonucleotides. Approval and registration The approval and registration process for therapeutic oligonucleotides, as for any other drug, is a critical step in their journey from the laboratory to the patient. This process involves […]

Clinical trials have been a fundamental pillar in the advancement of medicine and pharmaceutical research. Their evolution has been a testament to the human commitment to understand, improve and treat disease. These studies, involving the evaluation of treatments in humans, have been the cornerstone for determining the safety and efficacy of new therapies, and continue […]

In this sixth installment of our #DiscoveringOligonucleotides series, we delve into the synthesis and scale-up of therapeutic oligonucleotides. These small fragments of nucleic acids have proven to be crucial tools in the development of innovative and targeted drugs for a variety of medical conditions. Ensuring excellence in the production of therapeutic oligonucleotides: synthesis, purification and […]

In the fifth installment of our #DiscoveringOligonucleotides series, we dive into the preclinical development phase. From research in vitro, which lays the groundwork, until validation in vivo, which brings promising therapies to clinical reality, therapeutic oligonucleotides, like all other drugs, need to be studied in depth before being tested in patients. In vitro research: the […]

In this fourth installment of our #DiscoveringOligonucleotides series, we explore a crucial challenge for innovative drug development, including those based on therapeutic oligonucleotides: delivery systems. Challenges in the release of therapeutic oligonucleotides Therapeutic oligonucleotides have enormous potential to address a variety of diseases, from genetic disorders to neurodegenerative diseases. However, their efficacy is often linked […]

Therapeutic oligonucleotides represent a breakthrough technology in genetic medicine, specifically addressing diseases at the molecular level. In this third instalment of our #DiscoveringOligonucleotides series, we dive into the development process, from target finding to custom oligonucleotide design. Search and selection of new targets: innovative strategies In the search for more effective treatments, systems biology stands […]

In this second issue of #DiscoveringOligonucleotides, from the OLIGOFASTX consortium we want to introduce you to RNA therapeutics. In the field of medicine, RNA therapies stand as pioneers, offering new approaches and promising advances in the treatment of diseases hitherto thought unattainable. RNA therapies operate at the most fundamental level of genetic information, using different […]

Therapeutic oligonucleotides have emerged as an exciting and promising class of drugs capable of offering treatments for genetic and/or rare diseases. These DNA or RNA fragments have revolutionised the field of modern medicine… In this blog, we will explore what therapeutic oligonucleotides are, how they work and their potential applications, with a special focus on […]